Skin tags are thought to occur from skin rubbing up against skin, since they are so often found in skin creases and folds. Studies have shown existence of low-risk HPV 6 and 11 in skin tags, hinting at a possible role in its pathogenesis. Acrochorda have been reported to have a prevalence of 46% in the general population. A causal genetic component is thought to exist. They also are more common in women than in men. Acrochorda were once thought to be associated with colorectal polyps, but studies have shown no such connection exists. Rarely, they can be associated with the Birt–Hogg–Dubé syndrome, acromegaly, and polycystic ovary syndrome.
I went through the stages of grief. First, I lived in denial. Then I got angry. How could this have happened to me? I tried bargaining. "I will never sleep with anyone ever again if I just wake up and these things are gone." Then I slid into depression. I actually would never sleep with anyone again because who would want to sleep with someone, I thought, who had an STD? Never mind that even chronic STDs are manageable and treatable, and shouldn’t be stigmatized. I was raised to think these things didn’t happen to nice girls.
There is no evidence that removing a skin tag will cause more tags to grow. There is no expectation of causing skin tags to "seed" or spread by removing them. In reality, some people are simply more prone to developing skin tags and may have new growths periodically. Some individuals request periodic removal of tags at annual or even quarterly intervals.
Back in the 1980s, there was some speculation that skin tags were more common in people who went on to develop colon polyps or colon cancer. Subsequent research published in the Archives of Internal Medicine and the Journal of Clinical Gastroenterology, however, found no association. That means people with skin tags had no greater chance of developing colon polyps or cancer. The authors concluded skin tags should not be used as a reason for more intensive screening.
Most importantly, don’t take it upon yourself to decide that a growth is benign. At your dermatologist’s office, you’ll have a better shot at getting a solid read on what you have—and whether it’s an issue. And if you want it removed, most doctors will perform removal by freezing with liquid nitrogen (cryosurgery), cautery with an electric current (electrosurgery), or cutting with medical scissors (snip excision).
Insulin resistance, which may lead to type 2 diabetes and prediabetes, may also play a role in the development of skin tags. People with insulin resistance don’t absorb glucose effectively from the bloodstream. According to a 2010 study, the presence of multiple skin tags was associated with insulin resistance, a high body mass index, and high triglycerides.