The best method for mole removal depends on different characteristics of the mole including size, shape, and color. With most moles (pigmented areas) we are either born with them, or they appear over time as we exose our skin to the sun. For flat moles, skin tags, or protruding moles that have been relatively stable since birth (with no rapid growing, shape changing, etc.) treatment with laser or excision can remove them easily. Other moles that have changed in color or contour should be removed for biopsy to determine if they are associated with skin cancer.
Back in the 1980s, there was some speculation that skin tags were more common in people who went on to develop colon polyps or colon cancer. Subsequent research published in the Archives of Internal Medicine and the Journal of Clinical Gastroenterology, however, found no association. That means people with skin tags had no greater chance of developing colon polyps or cancer. The authors concluded skin tags should not be used as a reason for more intensive screening.