Insulin resistance, which may lead to type 2 diabetes and prediabetes, may also play a role in the development of skin tags. People with insulin resistance don’t absorb glucose effectively from the bloodstream. According to a 2010 study, the presence of multiple skin tags was associated with insulin resistance, a high body mass index, and high triglycerides.

While they can turn up anywhere, skin tags tend to appear where there is frequent friction, such as the neck, breasts, groin, and underarms. Ultimately, there is no evidence that skin tags will lead to any serious skin condition: They’re mostly an aesthetic annoyance. Regardless, most dermatologists encourage you to have them checked out—and removed, if you want. The only link to danger is from one study from the Indian Journal of Dermatology, which suggested that skin tags may be a sign of underlying heart issues. You could get your heart checked out, but the one research connection shouldn’t concern anyone too much.
First, the good news: Skin tags are benign and cause no symptoms. These harmless growths of skin can be right on the skin surface or seem to sprout from a thin stalk of skin and hang off the body. Also called cutaneous tags, soft fibromas, acrochordons, and fibroepithelial polyps, skin tags are mostly flesh-colored growths, although some may be darker in color.

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