Determine whether a biopsy is needed. At your appointment, the doctor will examine your mole's shape, borders, size, color, and surface texture, to see whether it appears to be cancerous. If the mole exhibits common symptoms of melanoma or another type of skin cancer, the doctor will order a biopsy to test whether cancer cells are present. If it doesn't, the doctor will be able to go ahead and remove the mole. The sample will often be sent for analysis even if the mole does not appear to be cancerous.